Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression. Nanoparticle-driven spleen remodeling allowed transplanted mouse, rat, and human islets to restore normal blood sugar in diabetic rodents and cynomolgus macaques.
In type 1 diabetes, the immune system destroys native beta cells, the insulin-producing cells housed within pancreatic clusters called islets of Langerhans...
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