Targeting just one of the genes – known as Spns2 – led to a three-quarters reduction in the spread of skin cancer tumours, pictured under the microscope,, the experts found
A new biological target for drugs to reduce the spread of tumours in cancer patients has been found by Wellcome Trust Sanger Institute. Published in Nature today, the study with genetically modified mice found 23 genes out of 810 unique genes that either increased or decreased the spread of skin tumour cells to the lungs. Many of these genes also caused an alteration in the immune system, such as changing the bodies’ ability to fight infection. The researchers showed that targeting one of these genes – Spns2 – led to a 3/4 reduction in tumour metastasis.
Removal of the Spns2 gene caused the largest change, reducing ...
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