Staphylococcus aureus tagged posts

Bacterial biofilms that develop around golden staph infections make treatment difficult and prolonged, but researchers have shown in laboratory work that the hybrid antibiotics they have developed can destroy staph biofilms.

Eradicating deadly staph using a new breed of antibiotics has revealed promising results in research released by QUT, to help overcome one of the biggest modern medical challenges.

The bacteria attach to medical devices including catheters, artificial joints, implants and patients’ burns and wounds, establishing bacterial biofilms, a leading cause of failing antibiotic therapies and chronic infections.

QUT resear...

1. Highlights • Quinolone antibiotics fail to kill bacterial populations at high density • Exhaustion of OXPHOS substrates drives bacterial persistence • Carbon and electron acceptor supplementation restores antibiotic activity • Metabolic priming of OXPHOS reverses tolerance in diverse bacterial species.  2.Sensitization to Cipro in Clinically Relevant Pathogens. 

MIT researchers have discovered a way to make bacteria more vulnerable to quinolones, which include ciprofloxacin and are often used to treat infections such as E coli and Staphylococcus aureus. The new strategy overcomes a key limitation of these drugs, which is that they often fail against infections that feature a very high density of bacteria...

bacterial biofilm

University of Birmingham and NIHR Surgical Reconstruction and Microbiology Research Centre (SRMRC) investigated antibacterial activity of acetic acid against key burn wound colonising organisms growing both planktonically and as biofilms.

Burns are a common traumatic injury and prone to becoming infected due to loss of a normal skin barrier. Local infection of the burn wound and subsequent sepsis are key concerns for patients, with sepsis the leading cause of death among patients with burn wounds. Infections of burn wounds are difficult to treat with traditional antibiotics as they do not effectively reach the wound, and the infecting organisms are often highly antibiotic resistant.

Low concentrations of acetic acid can be used to treat biofilms, and thus be used as alter...