Staphylococcus epidermidis tagged posts

Forget MRSA and E. coli. There’s another bacterium that is becoming increasingly dangerous due to antibiotic resistance – and it’s present on the skin of every person on the planet. A close relative of MRSA, Staphylococcus epidermidis, is a major cause of life-threatening infections after surgery, but it is often overlooked by clinicians and scientists because it is so abundant.

Researchers from the Milner Centre for Evolution at the University of Bath warn that the threat posed by this organism should be taken more seriously and use extra precautions for those at higher risk of infection who are due to undergo surgery.

They have identified a set of 61 genes that allow this normally harmless skin bacterium to cause life-threatening illness...

Highlights • Non-classical MHC class I molecules promote homeostatic immunity to the microbiota • Commensal-specific T cells express immunoregulatory and tissue repair signatures • Commensal-specific T cells accelerate wound closure

Insights may inform wound management techniques. Beneficial bacteria on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues.

Like humans and other mammals, mice are inhabited by the microbiome...