STAT2 binds STAT1 via high affinity N Domain interactions.
A protein known for guarding against viral infections leads a double life, new research shows, and can interfere with cell growth and the defense against parasites. Johnathan Ho and Uwe Vinkemeier at the University of Nottingham, UK, and colleagues describe the duplicitous nature of this essential protein, called STAT2, which they discovered while investigating the mechanisms behind interferon signaling.
Interferons are powerful antimicrobials that can also stop the proliferation of normal and cancer cells...
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