Mechanism of action of the identified STING antagonists.
Scientists have discovered two small-molecule compound series that can effectively block a central pathway of the innate immune system, offering a promising new way for treating autoinflammatory diseases. As a key strategy to sense the presence of pathogens, the cells of the innate immune system use receptors that can identify microbial DNA and in turn activate a protein called STING (STimulator of Interferon Genes). Once activated, STING turns on genes that help cells fight off the infecting pathogen.
Nonetheless, the innate immune system can turn against the body itself, causing a number of diseases, which are referred to as autoinflammatory...
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