stop breast cancer proliferation tagged posts

Researchers have discovered that the drug pioglitazone, used to treat diabetes, shows some ability to halt the overexpression of the protein NAF-1, which has been associated with the proliferation of breast cancer. (Credit: Illustration by Fang Bai/Rice University)

Dialing down the level of the protein NAF-1 and the activity of the iron-sulfur clusters it transports may be key to halting tumor growth. The researchers suggest a drug that is typically used to treat type 2 diabetes, pioglitazone, has proven effective at controlling NAF-1 levels. They also discovered that a single mutation to NAF-1 almost completely blocked the ability of cancer cells to proliferate, a result they said supports the idea that lowering NAF-1 expression can help stop tumors...