stop prostate cancer metastasis tagged posts

Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to metastasize, early in the course of the disease and whether it will respond to anti-androgen therapy, a common treatment for advanced disease. The new gene signature may also be useful for evaluating responses to treatment and for developing new therapies to prevent or treat advanced prostate cancer.

“If we could know in advance which patients will develop metastases, we could start treatments earlier and treat the cancer more aggressively,” says the study’s senior author, Cory Abate-Shen, PhD, chair of the Department of Molecular Pharmacology and Therapeutic...

mRNA expression in normal human tissues for ZMYND8 Gene

ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center. “These findings are important as cancer metastasis is a complicated process and is both devastating and clinically challenging,” said Min Gyu Lee, Ph.D., associate professor of Molecular and Cellular Oncology.

Alterations in histone modifications, including acetylation and methylation, are frequently associated with cancer development. Lee’s group looked at ZMYND8 as a histone “reader” that could possibly impact gene expression by recognizing these histone modifications known as histone “marks.”

“It has been well documented that the effects of histone acetylation and methyl...