Streptococcus pneumoniae tagged posts

Researchers have uncovered a crucial link between dietary zinc intake and protection against Streptococcus pneumoniae, the primary bacterial cause of pneumonia. Globally, it is estimated that nearly two billion people suffer from zinc deficiency, but why this increases susceptibility to bacterial infection has not been well understood – until now.

University of Melbourne Associate Professor Christopher McDevitt, a laboratory head at the Doherty Institute, led an interdisciplinary team using state-of-the-...

Figure shows the way that copies of the toxin pack together to form pores in cells. Credit: University of Leicester

It gives hope for developing Rx for pneumococcal diseases such as bacterial pneumonia, meningitis and septicaemia. The 3 yr study involving 4 research groups from across the University has been described as an exciting advance because it points to the possibility of creating therapeutics that block assembly of pneumolysin pores to treat people with pneumococcal disease.

Using X-ray crystallography at Diamond Light Source, UK’s national synchrotron science facility, the Leicester team was able to see the individual atoms of the toxin. The structure not only reveals what the toxin looks like, but also shows how it assembles on the surface of cells to form lethal pores...