Highlights • Genetic loss of PHD1 provides substantial protection against brain ischemic injury • PHD1 loss reprograms glucose metabolism without vascular changes • Increased oxPPP flux, at the expense of glycolysis, enhances redox balance in neurons • Intracerebroventricular delivery of anti-PHD1 oligos protects against stroke
Despite (minor) improvements in stroke treatment, stroke remains the 4th leading cause of death and the most common reason of severe disability. Research led by Prof. Peter Carmeliet and Dr. Annelies Quaegebeur (VIB/KU Leuven) indicates inhibition of PHD1 offers protection against stroke, via an unexpected mechanism, raising hope for future stroke treatment.
Brain cells rely on oxygen and glucose to generate energy, necessary to function normally...
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