Superagers tagged posts

For 25 years, scientists have studied “SuperAgers”—people aged 80 and above whose memory rivals those decades younger. Research reveals that their brains either resist Alzheimer’s-related plaques and tangles or remain resilient despite having them.

These individuals maintain a youthful brain structure, with a thicker cortex and unique neurons linked to memory and social skills. Insights from their biology and behavior could inspire new strategies to protect cognitive health into late life.

For the past 25 years, researchers at Northwestern Medicine have been examining people aged 80 and older, known as “SuperAgers,” to uncover why...

Research led by the Center for Biomedical Technology, Universidad Politécnica de Madrid, Spain, has compared the brains of superagers with those of normal cognitive aged abilities in a paper, “Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project,” published in The Lancet Healthy Longevity. A Comment published in the same journal issue discusses the work by the team.

Episodic memory, the memory of personal life experiences, is vulnerable to age-related deterioration. Neurodegenerative diseases like Alzheimer’s often lead to severe episodic memory decline.

Some older adults, called superagers, somehow resist age-related memory decline, maintaining episodic memory comparable to healthy indivi...