suprachiasmatic nucleus tagged posts

CRY1, cryptochrome circadian clock 1

New research describes a protein created by the body’s “biological clock” that actively represses inflammatory pathways within the affected limbs during the night. This protein, called CRYPTOCHROME, has proven anti-inflammatory effects in cultured cells and presents new opportunities for the development of drugs that may be used to treat inflammatory diseases and conditions, such as arthritis.

“By understanding how the biological clock regulates inflammation, we can begin to develop new treatments, which might exploit this knowledge,” said Julie Gibbs, Ph.D, University of Manchester, UK. “Furthermore, by adapting the time of day at which current drug therapies are administered, we may be able to make them more effective.”

To make this discovery, Gibbs a...

Before the delivery of the neurotoxin (left) the SCN oscillate in a synchronized pattern. After the delivery of the neurotoxin (right), neurons in the SCN oscillate randomly. Credit: Image courtesy of the Doyle Lab

For the 1st time it has been shown how neurons in the SCN are connected to each other, shedding light on this vital area of the brain. Understanding this structure – and how it responds to disruption – is important for tackling illnesses like diabetes and PTSD. The scientists have also found that disruption to these rhythms such as shifts in work schedules or blue light exposure at night can negatively impact overall health...