In this study, Drago and Davis show that inhibition of mitochondrial calcium entry in Drosophila mushroom body neurons during development impairs fly memory without altering their capacity to learn. In addition, they show associated defects in the structure and synaptic vesicle content of mushroom body neurons.
TSRI Scientists offer new insights how calcium in mitochondria can impact the development of the brain and adult cognition. In particular, the team showed in fruit flies, a widely used model system, that blocking a channel that brings calcium to the mitochondria, called “mitochondrial calcium uniporter,” causes memory impairment but does not alter learning capacity...
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