Illustration demonstrating the anti-cancer effect of the drug combination. Credit: Evi Bieler, NanoImaging Lab, University of Basel
A combination of a diabetes medication and an antihypertensive drug can effectively combat specific cancer cells. Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer. The team has now made an unexpected discovery: The antihypertensive drug syrosingopine potentiates the anti-cancer efficacy of metformin. Apparently, this drug combination drives cancer cells to programmed “suicide.”
At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induc...
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