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    T cell-based immunotherapy tagged posts

    Surprise finding shows that Neutrophils can be Key Antitumor Weapons

    April 4, 2023, Categories  Biology/Biotechnology, Health/Medical

    microscopic image
    Biopsies from melanoma patients who were treated or not with immune checkpoint blockade were stained for neutrophil activation. Left: Biopsy of an untreated patient, with white arrow showing neutrophils. Right: Biopsy of a patient treated with immunotherapy, with yellow arrows showing activated neutrophils. 

    White blood cells called neutrophils have an unappreciated role in eradicating solid tumors, according to a surprise discovery from a team led by Weill Cornell Medicine scientists.

    In the study, published March 30 in Cell, the researchers investigated how a T cell-based immunotherapy was able to destroy melanoma tumors even though many of the tumor cells lacked the markers or “antigens” targeted by the T cells...

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