tau protein biomarker tagged posts

High molecular weight tau bands (about 80kDa) can be appreciated, with greater immunoreactivity in patients with AD compared with healthy subjects. Credit: Dr. Ricardo B. Maccioni

Drs Maccioni and Farías have pioneered the technology that detects in human blood platelets the pathological oligomeric forms of brain tau protein in patients with Alzheimer’s disease (AD) and other neurodegenerative disorders. More importantly, the ratio between this anomalous tau and the normal tau protein can discriminate AD patients from normal controls, and are associated with decreased cognitive impairment. These studies open a new avenue in the development of highly sensitive and efficient biomarkers for neurodegenerative disorders...