TBI tagged posts

Brain volume measurement may provide early biomarker. Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder brought on by physical and/or psychological trauma. How its symptoms, including anxiety, depression and cognitive disturbances arise remains incompletely understood and unpredictable. Treatments and outcomes could potentially be improved if doctors could better predict who would develop PTSD. Now, researchers using magnetic resonance imaging (MRI) have found potential brain biomarkers of PTSD in people with traumatic brain injury (TBI).

The study appears in Biological Psychiatry: Cognitive Neuroscience a...

The “Autism & Beyond” app uses an iPhone’s self-facing camera to assess a child’s emotional state while viewing various stimuli. The dots are landmarks automatically placed on a video of the child by the software. Credit: Autism & Beyond

Thanks in part to support from Office of Naval Research (ONR), there’s an app that may screen for autism by reading kids’ facial expressions for emotional cues. “The long-term implications of this research are huge,” said Dr. Predrag Neskovic. “Not only could the app be used to learn more about childhood autism, it could possibly reveal signs of post-traumatic stress disorder [PTSD] and mild traumatic brain injury [TBI] in warfighters—conditions that often have subtle symptoms and are difficult to diagnose.”
The app, called “Autism & Beyond,” was develop...

It could lead to the development of new drugs to treat the disease. The study found that the protein fragment, sAPPα, inhibits the proteolytic enzyme BACE1. Increased BACE1 activity contributes to production of the amyloid beta aggregates and plaques that are the hallmark of Alzheimer’s.

“Because sAPPα inhibits the BACE1 enzyme, it may be possible that it can be used to help prevent potentially dangerous increases in BACE1 activity, and thus prevent the onset of Alzheimer’s disease,” A/Prof Varghese John.

The protein fragment sAPPa is normally produced by neurons and is involved in maintenance of memory...