TDP1 promotes mitochondrial gene transcription in human cells.
A 5-yr study has found the mechanism responsible for repairing damage to mitochondrial DNA. This discovery could pave the way for new treatments for cancer and neurodegenerative diseases. This research may also have important implications for clinical advances in so called ‘three-parent baby’ mitochondrial donation. They also show how the enzyme TDP1- already known to have a role in repairing damaged DNA in the cell’s nucleus – is also responsible for repairing damage to mitochondrial DNA (mtDNA).
During the process of energy production and making proteins, a large amount of rogue reactive oxygen species are produced which constantly attack the DNA in the mitochondria...
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