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    Telomere Length tagged posts

    Cellular Aging and Cancer development: New insight

    June 14, 2017, Categories  Biology/Biotechnology, Health/Medical

    Discovery by NUS researchers improves understanding of cellular aging and cancer development

    ZBTB48 binds through the last of its 11 zinc fingers directly to telomeric DNA (TTAGGG, in red) as well as subtelomeric variant repeats (TTGGG/TCAGGG, grey), which represent the protective caps at the end of chromosomes. In addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, MTFP1. In the absence of ZBTB48 (right panel) telomeres become longer whereas the expression of ZBTB48 target genes is strongly reduced. For instance, ZBTB48 KO (knock-out) cells loose the expression of MTFP1 leading to defects in the mitochondrial network with mitochondria clustering around the nucleus instead of being widely spread throughout the cell. Credit: National University of Singapore

    Medical researchers have discovered the role of the p...

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    Researchers discover Other Enzyme Critical to Maintaining Telomere Length

    November 13, 2015, Categories  Biology/Biotechnology, Health/Medical

    Telomeres glow at the end of chromosomes. Credit: Hesed Padilla-Nash and Thomas Ried of the NIH

    Telomeres glow at the end of chromosomes. Credit: Hesed Padilla-Nash and Thomas Ried of the NIH

    New method may speed understanding of short telomere diseases and cancer and the new method they used to find it should speed discovery of other proteins and processes that determine telomere length. “We’ve known for a long time that telomerase doesn’t tell the whole story of why chromosomes’ telomeres are a given length, but with the tools we had, it was difficult to figure out which proteins were responsible for getting telomerase to do its work,” saysProf. Carol Greider, Ph.D (winner of the 2009 Nobel Prize in Physiology or Medicine for the discovery of telomerase.)

    Figuring out exactly what’s needed to lengthen telomeres has broad health implications as shortened telomeres have been implicat...

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