tetramer tagged posts

This illustration shows how four copies of computer-designed transmembrane protein assembled to form a rocket-shaped tetramer with a wide cytoplasmic base that funnels into eight transmembrane helices and which orients correctly in membrane. Credit: University of Washington Institute for Protein Design

Advance paves the way for the design of transmembrane proteins with useful, new functions. It is now possible to create complex, custom-designed transmembrane proteins from scratch, scientists report this week. The advance, led by molecular engineers at the University of Washington Institute for Protein Design, will enable researchers to create transmembrane proteins not found in nature to perform specific tasks.

In the living world, transmembrane proteins are found embedded in the membrane ...

Images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease, have now been captured by researchers. Credit: Illustration: Per Uvdal

MAX IV synchrotron in Lund, Sweden – the strongest of its kind in the world – has been used to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease. The unique images appear to contradict a previously unchallenged consensus. Instead of attempting to eliminate beta-amyloid plaques, the researchers now suggest stabilizing the protein.

It is a long-held belief in the scientific community that the beta-amyloid plaques appear almost instantaneously. Hence the term “popcorn plaques...