Th17 tagged posts

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

This discovery, reported in Proceedings of the National Academy of Sciences (PNAS), could potentially lead to the development of selective HDAC inhibitors designed to treat types of IBD such as ulcerative colitis and Crohn’s disease.

“Our understanding of the specific function of class II HDACs in different cell types has been limited, impeding development of therapies targeting this promising drug target family,” says senior author Ming-Ming Zhou, PhD, Dr...

A molecule found in the venomous toadfish Thalassophryne nattereri has proven capable of controlling lung inflammation and could be the basis for a more effective asthma drug. The research was conducted by scientists at Butantan Institute in São Paulo, Brazil. An article describing the results is published in the journal Cells.

A welter of fish species live in freshwater, seawater, and a mixture of the two, and some of them are venomous. They have spines or stingers connected to venom glands, which are a kind of pouch full of molecules, large and small, that are toxins...