As control mice run along a track, the brain map of their environment isregularly updated through the neural circuitry in the hippocampus (left side of image). Without input from area CA3 in the hippocampus, the neural code that represents where the mutant mouse has come from (past coding) and is going (future coding) becomes disordered with only the current location remaining intact (right side of image). Credit: RIKEN
Neurons need well-waves of activity to organize memories across time. In the hippocampus, temporal ordering of the neural code is important for building a mental map of where you’ve been, where you are, and where you are going. RIKEN Brain Science Institute in Japan has pinpointed how the neurons that represent space in mice stay in time.
As a mouse navigates its environmen...
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