tissue regeneration tagged posts

Cartilage template formation via engineered extracellular matrix. Credit: Syam Nukavarapu/UConn Photo

A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury. There are over 200 bones in an adult human skeleton, ranging in size from a couple of millimeters in length to well over a foot. How these bones form and how they are repaired if injured varies, and has posed a challenge for many researchers in the field of regenerative medicine.

Two processes involved with human skeletal development help all the bones in our body form and grow. These processes are called intramembranous and endochondral ossification, IO and EO respectively...

Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Credit: © dedigrigoroiu / Fotolia

Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs. In a new study published in the journal Stem Cells, a team led by John P. Cooke, M.D., Ph.D, described how activation of innate immunity enhances nuclear reprogramming, one of the first steps in tissue regeneration, or the formation of new tissues and organs from a single cell in the body.

“We found that activating the innate immune system opens up the DNA,” said Cooke, the study’s senior author...

Schematic representation of this research.

These cells – capable of generating all cell types in the body – could be used as the ‘Lego bricks’ to build tissue constructs, larger structures of tissues, and potentially even micro-organs. “It was really exciting to see that we could grow embryoid body in such a controlled manner,” explains Wei Sun. “The grown embryoid body is uniform and homogenous, and serves as a much better starting point for further tissue growth.”

The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3D printing to produce a grid-like 3D structure to grow embryoid body with cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy.

Images of the printed cellular model with...