The tetrameric TOPLESS complex with the EAR motif peptides bound at its repressor-peptide binding grooves. The repressor peptides are shown as a ball presentation. Credit: Karsten Melcher, Ph.D., Van Andel Research Institute
Scientists at Van Andel Research Institute (VARI) have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer. In plants as in animals and humans, intricate molecular networks regulate key biological functions, such as development and stress responses. When the wrong switches are flipped, genes can be inappropriately turned on or off, leading to the onset of diseases.
“This is really a fundamental discovery –...
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