TRAIL tagged posts

Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized. Researchers have long assumed that astrocytes’ primary function is to provide nutrients and support for the brain’s more closely scrutinized nerve cells; over the years, however, increasing evidence has shown that astrocytes can also actively promote neurodegeneration, inflammation, and neurological diseases...

On the left is the schematic design of the TRAIL/Dox loaded platelet membrane-coated nanogel delivery system. The TRAIL is attached on the surface of membrane and Dox is loaded in the core of nanogel. On the right is a transmission electron microscope image of the drug delivery system. Black is the synthetic core nanogel, the outside shell is the platelet membrane. Credit: Quanyin Hu

It allows the drugs to last longer in the body and attack both primary cancer tumors and circulating tumor cells that can cause a cancer to metastasize. The work was tested successfully in an animal model. “There are two key advantages to using platelet membranes to coat anticancer drugs,” says assistant Prof Zhen Gu. “First, the surface of cancer cells has an affinity for platelets – they stick to each other...