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    transposable elements tagged posts

    ‘Jumping Genes’ help Stabilize DNA Folding Patterns

    January 26, 2020, Categories  Biology/Biotechnology, Health/Medical

    Fig. 2
    Contribution of TEs to the conservation landscape of human and mouse loops. a Flowchart describing the methodology used to annotate loop orthology. b Venn diagram representing the various classes of chromatin loops based on their orthology and bar plots showing the contribution of REs to anchor CTCFs of each class of loops. c Age distribution and age of individual TEs that contribute loop anchor CTCF sites (black dots for orthologous loops; gold dots for non-orthologous loops) (left), total contribution to loop anchor CTCF sites (middle), distribution of orthologous and non-orthologous loops (right) derived from the top 13 TE subfamilies in mouse and d humans. Estimated primate/rodent divergence time (82 million years ago) is from Meredith et al. [47]. e Contact maps representing a conse...
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    Advancing ‘Transposon Theory of Aging’

    September 16, 2016, Categories  Biology/Biotechnology, Health/Medical

    Activity with age. Fluorescence in the fat body of fruit flies tracks the activity of transposable elements of DNA. It increases markedly with age. Credit: Jason Wood/Brown University

    Activity with age. Fluorescence in the fat body of fruit flies tracks the activity of transposable elements of DNA. It increases markedly with age. Credit: Jason Wood/Brown University

    A new study increases and strengthens the links that have led scientists to propose the “transposon theory of aging.” Transposons are rogue elements of DNA that break free in aging cells and rewrite themselves elsewhere in the genome, potentially creating lifespan-shortening chaos in the genetic makeups of tissues. As cells get older, prior studies have shown, tightly wound heterochromatin wrapping that typically imprisons transposons becomes looser, allowing them to slip out of their positions in chromosomes and move to new ones, disrupting normal cell function...

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