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Potential Arthritis Treatment Prevents Cartilage Breakdown

Six days after treatment with IGF-1 carried by dendrimer nanoparticles (blue), the particles have penetrated through the cartilage of the knee joint.
Credit: Brett Geiger and Jeff Wyckoff

Injectable material made of nanoscale particles can deliver arthritis drugs throughout cartilage. In an advance that could improve the treatment options available for osteoarthritis, engineers have designed a new material that can administer drugs directly to the cartilage. The material can penetrate deep into the cartilage, delivering drugs that could potentially heal damaged tissue.

“This is a way to get directly to the cells that are experiencing the damage, and introduce different kinds of therapeutics that might change their behavior,” says Paula Hammond, head of MIT’s Department of Chemical Engineeri...

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