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    trimethylamine oxide (TMAO tagged posts

    Altering Gut Bacteria Pathways may Stimulate Fat Tissue to Prevent Obesity

    July 3, 2017, Categories  Biology/Biotechnology, Health/Medical

    Highlights •Plasma TMAO levels are elevated in type 2 diabetic patients •Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity •Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging •Inhibition of Fmo3 promotes resistance to obesity

    Highlights
    •Plasma TMAO levels are elevated in type 2 diabetic patients
    •Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
    •Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
    •Inhibition of Fmo3 promotes resistance to obesity

    Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

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