TRPM4 tagged posts

New Class of Highly Effective Inhibitors protects against Neurodegeneration

Interaction of interface inhibitors compound 8 and compound 19 within their binding pockets of the protein contact surface.
Interaction of interface inhibitors compound 8 and compound 19 within their binding pockets of the protein contact surface. | © Hilmar Bading

Neurobiologists at Heidelberg University have discovered how a special receptor at neuronal junctions that normally activates a protective genetic programme can lead to nerve cell death when located outside synapses. Their fundamental findings on neurodegenerative processes simultaneously led the researchers at the Interdisciplinary Center for Neurosciences (IZN) to a completely new principle for therapeutic agents. In their experiments on mouse models, they discovered a new class of highly effective inhibitors for protecting nerve cells. As Prof...

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