TRPV1 receptors tagged posts

The cause of abdominal pain in patients with irritable bowel syndrome has been identified by researchers. As a result, they were able to select a medicine that could reduce or end that pain. This medicine is already used to treat hay fever. IBS patients have extremely sensitive bowels associated with increased pain perception. The exact cause of this hypersensitivity has long been unknown. Researchers already knew that the bowels of patients with IBS contain larger quantities of the substance histamine, but the specific link with hypersensitivity had not yet been made.

KU Leuven professor of gastroenterology Guy Boeckxstaens and his team have now shown that histamine has an impact on the pain receptor TRPV1. In IBS patients, histamine released in the gut makes TRPV1 hypersensitive...

A high-fat diet may impair important receptors located in the stomach that signal fullness, researchers have discovered. They investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in lab studies, suggesting that their work will inform further studies and the development of new therapies.

“The stomach stretches when it is full, which activates nerves in the stomach to tell the body that it has had enough food. We found that this activation is regulated through hot chilli pepper or TRPV1 receptors,” says Associate Professor Amanda Page. “It is known from previous studies that capsaicin, found in hot chillies, reduces food intake in humans...