tumor growth tagged posts

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to
Promote Colorectal Tumorigenesis

The microbiota in the intestines fuels tumor growth. Scientists have made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumor growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases.

“With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation,” explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM...

Normal and cancerous pancreatic tissue. The blue background represents the cells that produce digestive juices supplied by the pancreas to the gut, and the red dots—seen only in the cancerous pancreas—represent the bacteria found to be a thousand times more abundant than normal.

Antibiotics may make immunotherapy more effective against pancreatic cancer. The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells. These are the findings of a study conducted in mice and in patients with pancreatic ductal adenocarcinoma (PDA), a form of cancer that is usually fatal within two years...