ubiquitin tagged posts

In a human cell, CHIP (red) is recruited to clusters of a dementia-inducing protein (yellow). There is not enough CHIP for insulin receptor degradation in this situation. The cell undergoes premature aging. (Photo: CECAD)

Researchers uncover the link between protein aggregation, aging. Early in evolution, sugar intake and the regulation of life span were linked with each other. The hormone insulin is crucial here. It reduces blood sugar levels by binding to its receptor on the cell surface. However, many processes for stress management and survival are shut down at the same time. When there is a good supply of food, they appear unnecessary to the organism, although this reduces life expectancy over the long term. The insulin receptor thus acts like a brake on life expectancy...