Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP)
A new technique is thousands of times more sensitive than current techniques in lab experiments, and it is now being put to test in real-world clinical trials. Tagging antibodies or related biomarkers involves designing a molecule that the biomarker will bind to, and which is adorned with an identifying “flag.” Through immunoassays, researchers can isolate that flag, and the biomarker bound to it, to provide a proxy measurement of the disease.
The new technique, developed in the lab of Prof. Carolyn Bertozzi, augments this standard procedure with powerful DNA screening technology...
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