uncoupling protein 1 tagged posts

Highlights •PM20D1 is a secreted enzyme that regulates N-acyl amino acids in vivo •N-acyl amino acids are endogenous metabolites that uncouple mitochondria •Increased PM20D1 or N-acyl amino acid administration augments energy expenditure

Findings show potential for obesity treatment. Investigators have identified a natural molecular pathway that enables cells to burn off calories as heat rather than store them as fat. This raises the possibility of a new approach to treating and preventing obesity, diabetes, and other obesity-linked metabolic disorders including cancer.

Prof. Bruce Spiegelman, PhD discovered the mechanism in energy-burning brown and beige fat cells in mice...