vaccine tagged posts

Called let-7, the microRNA governs formation of the cellular memory pool and is a gift from the dawn of animal life. A team of researchers at the University of Massachusetts Amherst has shown that a single, small strand of microRNA, or miRNA, known as let-7, governs the ability of T-cells to recognize and remember tumor cells. This cellular memory is the basis for how vaccines work. Boosting cellular memory to recognize tumors could help improve cancer therapies. The research, published recently in Nature Communications, suggests a new strategy for the next generation of cancer-fighting immunotherapies.

“Imagine that the human body is a fortress,” says Leonid Pobezinsky, associate professor of veterinary and animal sciences at UMass Amherst and the paper’s senior author, along with...

Yale scientists have developed a novel omicron-specific mRNA vaccine that offers superior immune protection against two viral subvariants than standard mRNA vaccines.

The new vaccine, called Omnivax, increased neutralizing antibody response against the BA.1 and BA.2.12.1 omicron subvariants in pre-immunized mice 19-fold and eight-fold, respectively, compared with standard mRNA vaccines. The improved response against the BA.1 subvariant was reported June 6 in the journal Nature Communications. The results of the study involving the BA.2 subvariant were published July 19 in the journal Cell Discovery.

“While standard mRNA vaccines still offer protection against infection from new variants, their effectiveness wanes over time and was compromised due...

Schematic and characterization of tri-agonist compound, Indole_Lox_CpG. (a) Chemical structure of covalently conjugated tri-agonist compound (Indole_Lox_CpG) (left). Diagram illustrating how each TLR agonist (pyrimido-indole, loxoribine, or CpG-ODN) and the corresponding combinations (Indole_Lox, Lox_CpG, or Indole_CpG) contributed to innate immune activation (right). (b) Confirmation of synthesized Indole_Lox_CpG via MALDI-TOF. (c) Analysis of Indole_Lox_CpG via gel electrophoresis: CpG-ODN1826 reference (lane 1) and Indole_Lox_CpG reaction mixture (lane 2). Tri-agonist was extracted from the gel and isolated as purified Indole_Lox_CpG.

Some vaccines, like the flu shot, contain a dead or weakened version of the disease-causing pathogen...