vitamin D tagged posts

Vitamin D Alters Mouse Gut Bacteria to give Better Cancer Immunity

Bacteroides fragilis
Photomicrograph showing Bacteroides fragilis, which normally lives in the human GI tract.   
Credit: CDC/ Dr. V.R. Dowell, Jr.

Researchers at the Francis Crick Institute, the National Cancer Institute (NCI) of the U.S. National Institutes of Health (NIH) and Aalborg University in Denmark have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.

Reported today in Science, the researchers found that mice given a diet rich in vitamin D had better immune resistance to experimentally transplanted cancers and improved responses to immunotherapy treatment. This effect was also seen when gene editing was used to remove a protein that binds to vitamin D in the blood and keeps it away from tissues.

Surprisingly, the team found th...

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The Sunshine Vitamin that ‘D’elivers on Cardio Health

hands in heart shape framing setting sun at sunset on beach

Free from the sun, vitamin D delivers a natural source for one of the hormones essential to our bodies, especially the bones. But when you’re down on this essential nutrient, it’s not only your bones that could suffer, but also your cardio health, according to new research from the University of South Australia.

In the first study of its kind, researchers from the UniSA’s Australian Centre for Precision Health at SAHMRI have identified genetic evidence for a role of vitamin D deficiency in causing cardiovascular disease.

The study, which is published in European Heart Journal today, shows that people with vitamin D deficiency are more likely to suffer from heart disease and higher blood pressure, than those with normal l...

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A good Vitamin D status can Protect against Cancer

Fig. 1
Vitamin D signaling. Production of vitamin D3 and its metabolites 25(OH)D3 and 1,25(OH)2D3 (A). VDR (green) binds accessible genomic DNA in complex with a partner protein (RXR or others, blue) (B). VDR’s DNA binding is supported by the pioneer factors PU.1, CEBPA and/or GABPA. The genomic region that can be influenced by 1,25(OH)2D3 (via binding to VDR) is restricted by CTCF proteins defining left and right TAD borders. Schematic representation of a Voronoi tessellation [55] displaying five TAD classes of the most prominently enriched biological processes (C). The most relevant attributes are the number of persistent and transient VDR sites and were chosen for the x and y axis, respectively.

A good vitamin D status is beneficial both in cancer prevention and in the prognosis of sever...

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Natural Sunscreen Gene influences how we make Vitamin D

Genetic variations in the skin can create a natural sunscreen, according to University of Queensland researchers investigating the genes linked with vitamin D.

Professor John McGrath from UQ’s Queensland Brain Institute said this was one of a number of ways vitamin D affected the body in a collaborative study that looked at the genomes of more than half a million people from the United Kingdom.

“This study has implicated several new skin-related genes that impact on our vitamin D status – distinct from skin colour which affects our ability to make vitamin D depending on the concentration of the pigment melanin in the skin,” Professor McGrath said.

“Vitamin D is the sunshine hormone and we need bright sunshine on the skin to make it, but variations in our genes also influence ...

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