wound healing tagged posts

The regenerative bandage promotes cell spreading and proliferation. The green spots are live cells entrapped in the hydrogel and stained with Calcein-AM. Credit: Ameer Research Lab, Northwestern University

Shape-conforming hydrogel leverages the body’s own healing mechanisms rather than releasing drugs or biologics. Researchers have developed a new device, called a regenerative bandage, that quickly heals painful, hard-to-treat sores without using drugs. During head-to-head tests, the new bandage healed diabetic wounds 33% faster than one of the most popular bandages currently on the market.

“The novelty is that we identified a segment of a protein in skin that is important to wound healing, made the segment and incorporated it into an antioxidant molecule that self-aggregates at body temp...

Rice University graduate student Nicole Carrejo analyzes a sample of K2(SL)6K2, an injectable hydrogel researchers believe may help accelerate the healing of diabetic ulcers. Credit: Jeff Fitlow/Rice University

Invention could accelerate tissue growth compared with current treatment. A hydrogel invented at Rice University that is adept at helping the body heal may also be particularly good at treating wounds related to diabetes. The Rice lab of chemist and bioengineer Jeffrey Hartgerink reported this week that tests on diabetic animal models showed the injectable hydrogel significantly accelerated wound healing compared with another hydrogel often used in clinics. The study appears this week in the American Chemical Society journal ACS Biomaterials Science and Engineering...

Highlights • Non-classical MHC class I molecules promote homeostatic immunity to the microbiota • Commensal-specific T cells express immunoregulatory and tissue repair signatures • Commensal-specific T cells accelerate wound closure

Insights may inform wound management techniques. Beneficial bacteria on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues.

Like humans and other mammals, mice are inhabited by the microbiome...

Efficient miR-92a downregulation in the skin upon treatment with caged antimiR-92a.

MicroRNAs are interesting target structures for new therapeutic agents. They can be blocked through synthetic antimiRs. However, to date it was not possible to use these only locally. Researchers at Goethe University Frankfurt have now successfully achieved this in the treatment of impaired wound healing with the help of light-inducible antimiRs.

MicroRNAs are small gene fragments which bond onto target structures in cells and in this way prevent certain proteins from forming. As they play a key role in the occurrence and manifestation of various diseases, researchers have developed what are known as antimiRs, which block microRNA function...