In a past study, NIH researchers examined blood flow in various brain regions while subjects summoned up feelings of gratitude (Zahn et al, 2009). They found that subjects who showed more gratitude overall had higher levels of activity in the hypothalamus. This is important because the hypothalamus controls a huge array of essential bodily functions, including eating, drinking and sleeping. It also has a huge influence on your metabolism and stress levels. From this evidence on brain activity it starts to become clear how improvements in gratitude could have such wide-ranging effects from increased exercise, and improved sleep to decreased depression and fewer aches and pains.
Furthermore, feelings of gratitude directly activated brain regions associated with dopamine, the “reward” neurotransmitter. But dopamine is also almost important in initiating action. That means increases in dopamine make you more likely to do the thing you just did. It’s the brain saying, “Oh, do that again.” https://www.psychologytoday.com/blog/prefrontal-nudity/201211/the-grateful-brain
http://www.scientificamerican.com/video/gratitude-on-the-brain/
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