mRNA expression in normal human tissues for ZMYND8 Gene
ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center. “These findings are important as cancer metastasis is a complicated process and is both devastating and clinically challenging,” said Min Gyu Lee, Ph.D., associate professor of Molecular and Cellular Oncology.
Alterations in histone modifications, including acetylation and methylation, are frequently associated with cancer development. Lee’s group looked at ZMYND8 as a histone “reader” that could possibly impact gene expression by recognizing these histone modifications known as histone “marks.”
“It has been well documented that the effects of histone acetylation and methylation on gene expression can be mediated by specific binding proteins called ‘readers,'” said Lee. “We identified ZMYND8 as a reader for histone marks called H3K4me1 and H3K14ac, both of which are tied to metastasis-linked genes.” The research group also noted that ZMYND8 cooperated with a type of histone mark “eraser” called JARID1D to suppress metastasis-linked genes.
“These findings are of special interest in light of our earlier study that JARID1D levels are lower in metastasized prostate tumors than in normal prostate and primary prostate tumors,” said Lee. “This study revealed a previously unknown metastasis-suppressive mechanism in which ZMYND8 counteracts the expression of metastasis-linked genes by reading dual histone marks H3K4me1 and H3K14ac and cooperating with JARID1D.” https://www.mdanderson.org/newsroom/2016/07/protein-zmynd8-tied-.html
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