Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).
If you’re an older adult, a 30 min workout may not be as effective, even at the cellular level, as it was when you were younger. According to a new study, age may play a significant role in a cell’s ability to respond to that activity. In the study, a group of men 18 to 30 yo were tested against a group of older men 55 years and older. Study participants were generally healthy, non-smokers, who were not taking antioxidant supplements in excess of a multivitamin, or any NSAID drugs for 2 weeks leading up to the experiment.
The 2 groups cycled for 30 min, with blood being drawn 6 different times measuring cell function and antioxidant response. For this study, the exercise intensity was relative to the individual’s age and maximal aerobic capacity determined during a screening.
“Through this study we were able to determine that an individual’s antioxidant response to exercise becomes suppressed with age,” said Traustadóttir an associate professor of biology. “Exercise is effective and critical for people of all ages, but this study shows that older adults do not achieve the same beneficial cellular responses as younger adults from a single bout of moderate exercise.”
The findings indicate a single session of submaximal aerobic exercise is sufficient to activate an important group of antioxidant genes at the whole cell level in both young and older adults. However, nuclear import of Nrf2, the regulator for this group of antioxidant genes, is impaired with aging. Nuclear import is required for Nrf2 to access the antioxidant gene targets. Together these data demonstrate for the first time the weakening of Nrf2 activity in response to exercise in older adults.
Traustadóttir’s ongoing research aims to identify molecular processes responsible for age-related cellular changes. By better understanding the molecular signals promoting beneficial effects of exercise, definitive recommendations could be made for improving the body’s reaction to oxidative stress, which could lower the risk for many chronic diseases.
http://www.newswise.com/articles/beneficial-effects-of-exercise-change-with-age
http://www.sciencedirect.com/science/article/pii/S0891584916300429
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