Category Biology/Biotechnology

Can the Heart Heal itself? New study says it can

A doctor examines a patient wearing a pink robe sitting on the edge of a bed
Tissue from patients with artificial hearts, or left ventricular assist devices, regenerated muscle cells at more than six times the rate of healthy hearts, according to a paper published in the journal Circulation.
Photo by Halfpoint Images via Getty Images

An international research team found evidence that heart muscle can regenerate after heart failure in some people with artificial hearts. A research team co-led by a physician-scientist at the University of Arizona College of Medicine — Tucson’s Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure. The results were published in the journal Circulation.

According to the Centers for Disease Control and Pr...

Read More

Introducing Perceptein, a Protein-based Artificial Neural Network in Living Cells

Here, each neuron is represented as spacecrafts, with their pilots in the cockpits depicted in the shape of protein 3D structures. These spacecrafts collectively process and transmit information to the final red neuron to make decisions on space navigation. The wires that connect the neurons, with the green substance inside, indicate the flow of biological information. Credit: Ehmad Chehre

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living cells that can process multiple signals and make decisions based on them.

The researchers have also introduced a unique term, “perceptein,” as a combination of protein and perceptron...

Read More

New Gene Therapy could Alleviate Chronic Pain, Researchers find

Researchers create gene therapy with potential to treat peripheral pain conditions
Credit: Cell (2024). DOI: 10.1016/j.cell.2024.11.001

Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm. But, sometimes injuries, nerve damage, or infections can cause long-lasting, severe bouts of pain that can make daily life unbearable.

What if there was a way to simply turn off pain receptors? UNC School of Medicine researchers Bryan L. Roth, MD, Ph.D., the Michael Hooker Distinguished Professor of Pharmacology, and Grégory Scherrer, PharmD, Ph.D., associate professor of cell biology and physiology and the UNC Neuroscience Center, have just proven that it is possible.

Using a tool designed by Roth in the early 2000s, the labs have created a new system that reduces acute and tissu...

Read More

Brain Regions that Relieve Effects of Chronic Stress in Mice Differ based on Sex

Schematic of cortical microcircuit showing connections among neurons and how activation of SST neurons leads to stress resilience
New research finds sex-specific regions of the brain can relieve the detrimental effects of chronic stress in male and female mice. Left: Schematic showing a cortical microcircuit with three types of interneurons expressing somatostatin (SST), parvalbumin (PV) or vasointestinal peptide (VIP) and their distinct patterns of innervation of glutamatergic output neurons (PNs), with thin lines representing axons that send chemical signals and the thicker lines of PNs representing dendrites that receive information. There is selective innervation of the distal ends of PN dendrites by axons of SST neurons...
Read More