Category Biology/Biotechnology

Smart probiotics can sense high blood sugar and release GLP-1 on demand

Smart probiotics can sense high blood sugar and release GLP-1 on demand
Conceptual diagram of an intervention for glycemic control based on a glucose-sensing probiotic (GIFT). GIFT cells are orally administered to diabetic mice and monkeys, temporarily colonize the intestine and secrete GLP-1 in response to high glucose levels, leading to an abolishment of persistent hyperglycemia. Credit: Nature (2026). DOI: 10.1038/s41586-026-10909-6

For people living with diabetes, managing blood sugar can mean constantly watching the clock, keeping meals and medications on schedule and staying alert to changes in glucose levels. While little can be done about timed meals, researchers have developed a biological system that detects rising blood sugar levels and automatically responds by releasing medication to bring glucose back down.

In a recent study published in...

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Blood proteins may flag disability risk years before loss of independence

Towards early disability prediction with blood protein biomarkers
Researchers identified two blood proteins—beta-2-microglobulin (B2M) and cystatin C—that predict future disability in community-dwelling adults aged 85 years and older. The findings, validated in independent Japanese and Italian aging cohorts, suggest that blood-based biomarkers could support earlier identification of older adults at risk of losing independence and guide timely preventive interventions. Credit: Dr. Yusuke Osawa from Keio University, Japan

Japan has one of the world’s fastest-aging populations, but maintaining independence into very old age remains a growing public health challenge...

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Why memories get fuzzier with age—and what replaces them

memory
Credit: Pixabay/CC0 Public Domain

Research from the University of East Anglia shows how our memories change with age and why specific details associated with past events can fade over time. The new study reveals that as people age, they not only remember fewer details from their past—but also struggle more when switching between different types of memories.

The work is published in the journal Psychology and Aging. It points to a shift in how we remember things as we age—where vivid, moment-specific recollections gradually give way to broader, more generalized knowledge.

Rather than portraying memory decline as a simple loss, the study offers a nuanced picture of aging cognition and sheds light on how memory evolves over a lifetime...

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How old are you really? Study explains what makes ‘epigenetic clocks’ tick, debuts new prediction tools

candles on cake
Credit: Unsplash/CC0 Public Domain

What do “epigenetic clocks” actually measure? These lab tests have become popular tools for studying biological aging, or how the body’s cellular function changes at a faster or slower rate than expected. However, the underlying biology behind each of these measurements has remained largely unknown until now.

A recent USC Leonard Davis School of Gerontology-led study published in npj Aging shows that five of the most widely used epigenetic clocks measure different aspects of biological aging. The research team also developed new gene expression-based clocks to complement existing epigenetic clocks, which show even stronger predictive power for age-related disease and mortality.

Biology versus the calendar
Scientists have long known that people ag...

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