A newly developed method called ReapTEC allowed the discovery of thousands of active bidirectional enhancers. Further analysis of GWAS data revealed that various immune-mediated diseases, like multiple sclerosis and rheumatoid arthritis, are related to genetic variations within these enhancers.
Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical Sciences (IMS) and Kyoto University in Japan and IFOM ETS in Italy have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma...
Fluorescence microscopic imaging of the skin treated with the aptamer cream: – The aptamers (here marked in pink) were applied to the top layer of the skin in the form of an ointment and also penetrate into the deeper dermal layers (nucleus: blue; antigen-presenting cells: green). Credit: Marlene Gottschalk
Researchers at the University of Bonn have isolated a DNA molecule that is suitable for combating allergic contact dermatitis in mice. The aptamer binds to certain immune system messenger substances, rendering them ineffective. This even works if the active ingredient is applied to the skin in the form of an ointment.
The working groups involved hope that aptamer creams such as this could also be suitable for treating other skin conditions...
Researchers at Tsinghua University recently introduced a new neuromorphic computational architecture designed to replicate the organization of synapses (i.e., connections between neurons) and the tree-like structure of dendrites (i.e., projections extending from the body of neurons).Read More
Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.
Direct neuronal reprogramming, a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.
In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding...
Recent Comments