Category Biology/Biotechnology

‘Supportive’ brain cells may actively drive cognitive decline

brain cell
Credit: Pixabay/CC0 Public Domain

Brain cells that produce the protective coating around nerve fibers can become dysfunctional with age and may actively contribute to cognitive decline, according to new research.

A study found that people with more severe cognitive decline had changes to nerve fibers and myelin—the protective coating around nerve fibers that helps messages travel efficiently through the brain. The study is published in the journal Nature Medicine.

Experiments in mice showed that disrupting oligodendrocytes—the cells that produce myelin—also altered the coating and impaired cognitive performance.

Experts say the findings overturn the longstanding view that these cells are always supportive of healthy brain function and could pave the way for new treatment...

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Intermittent fasting reveals gut-brain pathway that may reduce chronic pain

Intermittent fasting alters gut bacteria and reduces pain sensitivity in mice
Key findings of the current study. Credit: Dr. Xin Ding

Chronic pain, pain that persists or returns for more than three months, can affect people’s emotional well-being and is often accompanied by difficulty concentrating or remembering things. While they can be effective for some patients, available treatments for chronic pain do not always relieve all the other symptoms associated with it.

Some medical researchers have been exploring the potential of dietary interventions to relieve chronic pain and other connected symptoms. One of these is intermittent fasting, which entails alternating set periods of eating with periods during which people drink only water or unsweetened tea and coffee.

Researchers at Zhengzhou University and its First Affiliated Hospital recently conducted a...

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Smart probiotics can sense high blood sugar and release GLP-1 on demand

Smart probiotics can sense high blood sugar and release GLP-1 on demand
Conceptual diagram of an intervention for glycemic control based on a glucose-sensing probiotic (GIFT). GIFT cells are orally administered to diabetic mice and monkeys, temporarily colonize the intestine and secrete GLP-1 in response to high glucose levels, leading to an abolishment of persistent hyperglycemia. Credit: Nature (2026). DOI: 10.1038/s41586-026-10909-6

For people living with diabetes, managing blood sugar can mean constantly watching the clock, keeping meals and medications on schedule and staying alert to changes in glucose levels. While little can be done about timed meals, researchers have developed a biological system that detects rising blood sugar levels and automatically responds by releasing medication to bring glucose back down.

In a recent study published in...

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Blood proteins may flag disability risk years before loss of independence

Towards early disability prediction with blood protein biomarkers
Researchers identified two blood proteins—beta-2-microglobulin (B2M) and cystatin C—that predict future disability in community-dwelling adults aged 85 years and older. The findings, validated in independent Japanese and Italian aging cohorts, suggest that blood-based biomarkers could support earlier identification of older adults at risk of losing independence and guide timely preventive interventions. Credit: Dr. Yusuke Osawa from Keio University, Japan

Japan has one of the world’s fastest-aging populations, but maintaining independence into very old age remains a growing public health challenge...

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