Category Biology/Biotechnology

SARS-CoV-2 can Infect Dopamine Neurons causing Senescence

SARS-CoV-2 can infect dopamine neurons causing senescence
Stained tissue from the midbrain of a COVID-19 patient shows DNA in the cells’ nuceli (blue), dopamine neurons (green) and phosphor-alpha-synuclein (red). Credit: Liuliu Yang

A new study reported that SARS-CoV-2, the virus that causes COVID, can infect dopamine neurons in the brain and trigger senescence—when a cell loses the ability to grow and divide. The researchers from Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Columbia University Vagelos College of Physicians and Surgeons suggest that further research on this finding may shed light on the neurological symptoms associated with long COVID, such as brain fog, lethargy, and depression.

The findings, published in Cell Stem Cell on Jan...

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Research demonstrates that Killer T cells can support Tissue Regeneration

Killer T cells support tissue regeneration
Wound healing and target killing are both effector mechanisms of CD8 T cells. (A) Combined proliferation and killing assay in the presence of influenza-specific CD8 T cells and varying amounts of pulsed peptides on MRC-5 and HaCaT cells seeded in a 30:70 ratio. Left, representative image with labels (0 versus 5 h; T cells only versus T cells + 100 ng/ml peptide). Right, representative quantification of Cas3/7 activity (green) and HaCaT proliferation (red) with titrated amounts of influenza peptide, with statistical verification across experiments using normalized area under the curve (AUC, n = 3, one-way ANOVA, symbols indicate individual experiments). Scale bars = 400 µm; enhanced for improved visibility...
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Novel Regulator of Immune Evasion in Cancer identified

Novel regulator of immune evasion in cancer identified
Representative images from immunohistochemical staining of PD-L1, ATXN3, IRF1, and HIF-2α in human lung adenocarcinoma (LUAD) and melanoma patients. Courtesy of Deyu Fang, PhD. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI167728

Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future antitumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.

“The study provides a molecular insight into understanding why some cancer patients cannot be treated by the checkpoint blockade antitumor therapy, but others can,” said Deyu Fang, Ph.D...

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New Fuel Cell Harvests Energy from Microbes in Soil to Power Sensors, Communications

New fuel cell harvests energy from microbes in soil to power sensors, communications
The clean fuel cell in the lab. Credit: Bill Yen/Northwestern University

A Northwestern University-led team of researchers has developed a new fuel cell that harvests energy from microbes living in dirt.

About the size of a standard paperback book, the completely soil-powered technology could fuel underground sensors used in precision agriculture and green infrastructure. This potentially could offer a sustainable, renewable alternative to batteries, which hold toxic, flammable chemicals that leach into the ground, are fraught with conflict-filled supply chains and contribute to the ever-growing problem of electronic waste.

To test the new fuel cell, the researchers used it to power sensors measuring soil moisture and detecting touch, a capability that could be valuable for track...

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