Category Biology/Biotechnology

Researchers Identify ‘Switch’ to Activate Cancer Cell Death

A graphic shows two circles in blue and gold representing tumor cells and a red circle representing CAR-T immunotherapy.
An antigen-negative tumor cell, shown in the golden color on the right, is killed by Fas-mediated “bystander” killing.

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die. This new ability to trigger programmed cell death could open the door for improved cancer treatments. The findings were published Oct. 14 in the Nature journal Cell Death & Differentiation.

CD95 receptors, also known as Fas, are called death receptors. These protein receptors reside on cell membranes. When activated, they release a signal that causes the cells to self-destruct.

Modulating Fas may also extend the benefits of chimeric antigen receptor (CAR) T-cell th...

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Mimics Human Tissue, Fights Bacteria: New Biomaterial hits the sweet spot

Gloved hand holding a phial
The ‘Trpzip’ material will reform after being squished, fractured, or after being expelled from a syringe. Photo: UNSW Sydney

Scientists at UNSW Sydney have created a new material that could change the way human tissue can be grown in the lab and used in medical procedures.

The new material belongs to a family of substances called hydrogels, the essence of life’s ‘squishy’ substances found in all living things, such as cartilage in animals and in plants like seaweed. The properties of hydrogels make them very useful in biomedical research because they can mimic human tissue, allowing cells to grow in a laboratory.

There are also human-made hydrogels that are used in a broad range of commodity products ranging from food and cosmetics to contact lenses and absorbent materials, and ...

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Plant-based Materials give ‘Life’ to Tiny Soft Robots

Soft robot in a maze

A team of University of Waterloo researchers has created smart, advanced materials that will be the building blocks for a future generation of soft medical microrobots.

These tiny robots have the potential to conduct medical procedures, such as biopsy, and cell and tissue transport, in a minimally invasive fashion. They can move through confined and flooded environments, like the human body, and deliver delicate and light cargo, such as cells or tissues, to a target position.

The tiny soft robots are a maximum of one centimetre long and are bio-compatible and non-toxic. The robots are made of advanced hydrogel composites that include sustainable cellulose nanoparticles derived from plants.

This research, led by Hamed Shahsavan, a professor in the Department of Chemical Engine...

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NUS scientists develop Innovative Magnetic Gel that Heals Diabetic Wounds Three Times Faster

2023 1019 NN_magnetic gel-1
Asst Prof Andy Tay (centre) is holding a plaster pre-loaded with magnetic gel, which promises to accelerate the healing of diabetic wounds, while Dr Shou Yufeng (right) is holding the device for magnetic stimulation. Dr Le Zhicheng (left) is holding a sample of the magnetic gel in liquid form.

First-of-its-kind cell therapy promotes wound healing, improves overall wound health and lowers risks of recurrence. A team of researchers has engineered an innovative magnetic wound-healing gel that promises to heal diabetic wounds three times faster, reduce the rates of recurrence, and in turn, lower the incidents of limb amputations...

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