Category Biology/Biotechnology

New, more Sustainable Method for Manufacturing Microchips and other Nanoscale Devices

A colorful sheet of fabricated semiconductors. A new water-based method for  manufacturing semiconductors could replace use of toxic chemicals and open the door for hybrid electronic-biological devices
“This opens up a huge opportunity in device fabrication,” said Fiorenzo Omenetto. “Not only can one deposit water-soluble materials and metals on silicon, but on all sorts of polymers.” Photo: Shutterstock

Putting 50 billion transistors into a microchip the size of a fingernail is a feat that requires manufacturing methods of nanometer level precision—layering of thin films, then etching, depositing, or using photolithography to create the patterns of semiconductor, insulator, metal, and other materials that make up the tiny working devices within the chip.

The process relies heavily on solvents that carry and deposit materials in each layer—solvents that can be difficult to handle and toxic to the environment.

Now researchers led by Fiorenzo Omenetto, Frank C...

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Ketogenic Diet may Reduce Friendly Gut Bacteria and raise cholesterol levels

Keto diet on a plate
Source: Adobe Stock

Published in Cell Reports Medicine, the research from the Centre for Nutrition, Exercise, and Metabolism involved 53 healthy adults for up to 12 weeks. Participants followed either a moderate sugar diet (control), a low-sugar diet (less than 5% of calories from sugar), or a ketogenic (keto) low-carbohydrate diet (less than 8% of calories from carbohydrates).

Key findings include:

Increased Cholesterol: The keto diet raised cholesterol levels, particularly in small and medium sized LDL particles. The diet increased apolipoproteinB (apoB), which causes plaque buildup in arteries. In contrast, the low-sugar diet significantly reduced cholesterol in LDL particles.

Reduced Favourable Gut Bacteria: The keto diet altered gut microbiome composition, notably decreas...

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Soft Gold enables Connections between Nerves and Electronics

Close-up illustrating that the gold nanowires combined with soft silicon rubber are stretchable.
The soft electrodes developed by Klas Tybrandt’s research group at Linköping University are stretchable to follow the body’s movements without damaging tissue. They consist of extremely thin threads of gold and soft silicone rubber.THOR BALKHED

Gold does not readily lend itself to being turned into long, thin threads. But researchers at Linköping University in Sweden have now managed to create gold nanowires and develop soft electrodes that can be connected to the nervous system. The electrodes are soft as nerves, stretchable and electrically conductive, and are projected to last for a long time in the body.

Some people have a “heart of gold,” so why not “nerves of gold”? In the future, it may be possible to use this precious metal in soft interfaces to connect electronics to the ...

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New Biomaterial Regrows Damaged Cartilage in Joints

New biomaterial regrows damaged cartilage in joints
A microscropy image of the new biomaterial. Nanofibers are pink; hyaluronic acid is shown in purple. Credit: Samuel I. Stupp/Northwestern University

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model.

Although it looks like a rubbery goo, the material is actually a complex network of molecular components, which work together to mimic cartilage’s natural environment in the body.

In the new study, the researchers applied the material to damaged cartilage in the animals’ knee joints...

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