Category Biology/Biotechnology

Human-approved Medication Brings Back ‘Lost’ Memories in Mice

Human-approved medication brings back 'lost' memories in mice
High magnification image showing part of the mouse hippocampus in which a sparse population of neurons encoding a specific learning event are labelled in red. Neurons that are not activated by the learning event are shown in blue. | Illustration Havekes Lab, University of Groningen

Students sometimes pull an all-nighter to prepare for an exam. However, research has shown that sleep deprivation is bad for your memory. Now, University of Groningen neuroscientist Robbert Havekes discovered that what you learn while being sleep deprived is not necessarily lost, it is just difficult to recall.

Together with his team, he has found a way to make this “hidden knowledge” accessible again days after studying while sleep-deprived using optogenetic approaches, and the human-approved asthma drug...

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Scientists develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Scientists develop a cancer vaccine to simultaneously kill and prevent brain cancer
Scientists developed a bifunctional therapeutic strategy by transforming living tumor cells into a therapeutic. Shah’s team engineered living tumor cells using the gene editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agent. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag and remember, priming the immune system for a long-term anti-tumor response. The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains including the one that bore bone marrow, liver and thymus cells derived from humans, mimicking the human immune microenvironment...
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Actinidia arguta (sarunashi) Juice Inhibits Lung Cancer in Mice, study finds

sarunashi

Using a mouse model, Japanese researchers unleash the likely mechanism of action of Sarunashi juice on lung cancer development. Among all the cancers, lung cancer has one of the lowest five-year survival rates. Smoking tobacco and using tobacco-based products is known to heavily contribute to the development of lung cancer. It is a clinically established fact that the active ingredients in various fruits minimize the risk of chronic diseases including cancer. “Sarunashi” (Actinidia arguta) is an edible fruit cultivated in Japan’s Okayama Prefecture. Using a mouse model, researchers from Okayama University led by Dr...

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Time-restricted eating reshapes gene expression throughout the body

Time-restricted eating reshapes gene expression throughout the body. In this illustration, the Ferris wheel displays the interconnected organ systems working smoothly during time-restricted eating, which is represented by the clock in the middle.
Credit: Salk Institute

Salk researchers find that timing calorie intake synchronizes circadian rhythms across multiple systems in mice. Scientists show in mice how time-restricted eating influences gene expression across more than 22 regions of the body and brain. The findings have implications for a wide range of health conditions where time-restricted eating has shown potential benefits, including diabetes, heart disease, hypertension, and cancer.

Numerous studies have shown health benefits of time-restricted eating including increase in l...

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