Category Biology/Biotechnology

Brief Anger may Impair Blood Vessel Function

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A brief episode of anger triggered by remembering past experiences may negatively impact the blood vessels’ ability to relax, which is essential for proper blood flow, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

Previous research has found that impairment of blood vessels’ ability to relax may increase the risk of developing atherosclerosis, which may, in turn, increase the risk of heart disease and stroke.

“Impaired vascular functi...

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Bacteria ‘Nanowires’ could help Develop Green Electronics

Bacteria 'nanowires' could help develop green electronics
Structure of γPFD filaments and incorporation of heme to make conductive nanowires. a) Filament assembly of γPFD through β-sheet domains, and b) proposed binding of heme molecules to the coiled-coil domains to form γPFD-heme nanowires. c) Protein-ligand binding isotherm with 30 µm of γPFD and varying concentration of heme, which indicates a stochiometric ratio of ≈1 heme per γPFD subunit in filaments. d) TEM image of the γPFD-heme nanowires. Credit: Small (2024). DOI: 10.1002/smll.202311661

Engineered protein filaments originally produced by bacteria have been modified by scientists to conduct electricity...

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Clogged Arteries Worsened by Cells that Behave like Cancer Cells

Columbia University researchers have found cells inside clogged arteries share similarities with cancer and aggravate atherosclerosis, raising the possibility that anticancer drugs could be used to treat atherosclerosis and prevent heart attacks.

Their study found that smooth muscle cells that normally line the inside of our arteries migrate into atherosclerotic plaques, change their cell identity, activate cancer genes, and proliferate inside the plaques.

“Our study shows that these transformed muscle cells are driving atherosclerosis, opening the door to new ways to treat the disease, potentially with existing cancer drugs,” says Muredach Reilly, MD, the Florence and Herbert Irving Endowed Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons ...

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People with Rare Longevity Mutation may also be Protected from Cardiovascular Disease

Jaime Guevara-Aguirre, Valter Longo, and several of the Laron study participants at the USC Leonard Davis School in Los Angeles.
Jaime Guevara-Aguirre (back left), Valter Longo (back right), and several of the Laron study participants at the USC Leonard Davis School in Los Angeles.

Patients with growth hormone receptor deficiency, or Laron syndrome, appear to have lower than average risk factors for cardiovascular disease, according to a new study.

A new study highlights possible cardiovascular health advantages in individuals with a rare condition known as growth hormone receptor deficiency (GHRD), also called Laron syndrome.

GHRD, which is characterized by the body’s impaired ability to use its own growth hormone and results in stunted growth, has been linked in mice to a record 40% longevity extension and lower risks for various age-related diseases...

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