Category Biology/Biotechnology

A Mount Sinai-led research team has demonstrated that autoimmunity, in which the body’s immune system attacks its own tissues, is responsible for the often-debilitating and confounding symptoms of long COVID in a subset of people.

Findings from the study, published in Cell, could lead to important new approaches to treating patients with long COVID, including already-validated therapies for management of autoimmunity as well as new ways of clinically identifying which patients are most likely to benefit from these therapies.

Autoimmunity emerges as key driver
“We’ve known for some time that long COVID involves not just one but a variety of phenotypes, and now we have validated that autoimmunity is a major contributor to the symptom burden,” says David Putrino, Ph.D...

At age 49, Jan Janisch-Hanzlik’s multiple sclerosis was destroying her freedom to live the life she wanted. She gave up her active nursing job for a desk role. Frequent falls made her afraid to carry her grandchildren. She had to move to a bigger house to make room for the wheelchair she feared she might end up needing full-time.

Even the best available medication wasn’t improving Janisch-Hanzlik’s symptoms, and she worried they’d only get worse...

Researchers have a better understanding of the nocebo effect and the neuroscience behind it all. Opposite of the better-known placebo effect, where positive expectations trigger genuine pain relief, the nocebo effect is the experience from negative expectations, created by prior experience, verbal suggestion, or social observation, which can drive anxiety and make pain worse.

A new study published in Nature Communications, by researchers at the University of Toronto Mississauga and McGill University, identified a brain pathway through which negative expectations can amplify pain. The findings, generated independently by the two labs without prior coordination, converged on the neurochemical cholecystokinin (CCK), which has previously been linked to nocebo pain responses in humans.

Forgiving someone might not erase painful memories, but it can subtly update them, making past hurts feel less upsetting. It’s less “forgive and forget,” and more “forgive and update.”

Psychologists have long known that forgiveness is crucial for healing rifts and keeping social bonds strong. Folk wisdom even advises us to “forgive and forget” after a wrong, implying that saying you forgive someone should make the bad memory vanish.

But forgiving doesn’t actually make you forget, notes Duke neuroscientist Felipe de Brigard: “When you forgive someone for a wrongdoing, you don’t forget the event. But once you forgive, the memory doesn’t hurt as much...