Category Biology/Biotechnology

Neutrophils promote irregularities while macrophages protect against them. Patients with heart disease are at risk of experiencing a potentially lethal “electrical storm” involving recurrent episodes of a type of irregular heartbeat called ventricular tachycardia (VT).

Electric shock therapy is used to treat VT following a heart attack, but unfortunately, options to prevent its recurrence are limited.

New research led by investigators at Massachusetts General Hospital (MGH) reveals that two different white blood cell types influence VT in the heart, suggesting that treatments that influence these cells may help reduce patients’ risk of sudden cardiac death.

The work, which is pu...

Senescent cells — those that have lost the ability to divide — accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. In a new study, a team led by University of Pittsburgh and UPMC Hillman Cancer Center researchers has uncovered a mechanism by which senescent, or “zombie,” cells develop.

Published today in Nature Structural & Molecular Biology, the stud...

Newly identified brain circuits may point to more effective pain therapies. An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform development of safer methods to treat pain, were published in Science. The study was led by researchers at the National Institute of Dental and Craniofacial Research (NIDCR); the University of Science and Technology of China, Hefei; and Anhui Medical University, Hefei, China. NIDCR is part of the National Institutes of Health.

“We need more effective methods of managing acute and chronic pain, and that starts...

Biologists have used population genomics to shed light on the evolution and consequences of a selfish genetic element known as Segregation Distorter (SD). The researchers report that SD has caused dramatic changes in chromosome organization and genetic diversity.

The human genome is littered with “selfish genetic elements,” which do not seem to benefit their hosts, but instead seek only to propagate themselves...